IVF is an advanced treatment for people who have trouble having a baby. The IVF technique is often recommended by health professionals to couples with fertility problems. During this procedure, the egg which is formed in a woman's ovaries is removed and fertilized with man’s sperm in the laboratory. Then the embryo which is formed after the fusion of sperm with egg is again returned to the woman’s body where the embryo will grow into the baby. IVF technique is not for all couples with difficulty in getting pregnant. The health professional first guides the couple on how to increase the chances of having a baby. And after a failure of many techniques, IVF may be helpful. IVF Treatment in India offers hope to those couples who are facing fertility challenges but it can be a complex procedure with physical, emotional, and financial complications. The success rates of IVF Treatment in India can vary depending on factors such as age, underlying infertility causes, and the quality of the embryos. Reproductive specialist guides the individual with circumstances, expectations, and any risks or side effects that are associated with IVF. IVF Treatment has provided many couples with the opportunity to fulfill their dreams of starting a family. Advances in technology and ongoing research continue to improve success rates and broaden the options available in assisted reproductive techniques.
The historical background of IVF (In Vitro Fertilization) and the success of IVF in decades are described below:
In the 1800s, scientists started experimenting on the fertilization that can happen outside the human body by using different animal species. In 1890, Walter Heape successfully achieved the first artificial insemination in rabbits.
In the early 1960s, Edwards collaborated with gynecologist Patrick Steptoe to develop techniques for human IVF. They faced multiple challenges, including obtaining viable eggs and successfully fertilizing them outside the body. In 1969, Edwards and Steptoe achieved the first successful human IVF by fertilizing an egg in a laboratory dish, but the embryo did not implant in the uterus.
On July 25, 1978, Louise Brown, the world's first "test-tube baby," was born in the United Kingdom. Edwards and Steptoe's successful IVF procedure led to Brown's conception, marking a major milestone in reproductive medicine.
IVF has continued to evolve, with ongoing advancements in laboratory techniques, frozen embryo transfer, genetic screening, and personalized treatment approaches. The development of fertility preservation techniques, including egg freezing, has also expanded options for individuals seeking to preserve their fertility.
Some common types of IVF Treatmet procedures are described below:
This is the common type of IVF Treatment in India method where a woman's ovaries are stimulated to produce various mature eggs. The eggs are then removed and fertilized in the laboratory with their partner’s sperm. After the fertilization, the resulting embryo after the fertilization of eggs and sperm is kept under the suitable environment in the laboratory. After a few days, the embryo is implanted into the uterus.
ICSI is used when there are infertility issues in male, such as low count of sperms or poor movement of sperms. In this technique, a single sperm is injected directly into each mature egg for fertilization. The remaining steps are similar to the conventional IVF procedure.
In FET, embryos that were not transferred during a previous IVF cycle are frozen for future use. These frozen embryos can be reused and transferred to the uterus in the next cycle, if needed. It allows more controlled and less invasive procedures.
In a blastocyst transfer, embryos are cultured for a longer period, typically around five to six days in the laboratory before being transferred to the uterus. This allows for better embryo selection as only embryos that have reached the more advanced stage of development are chosen for transfer.
PGT involves testing embryos for genetic abnormalities before transfer. This is usually helpful for individuals or couples with genetic disorders or those who have experienced multiple failed cycles of IVF. PGT can help in selecting the healthiest embryos for transfer which increases the chances of a successful pregnancy.
The candidates for IVF are the couple that are infertile due to any of the following reason:
Ovulation disorder: the female may have a condition in which the ovulation can be affected. If the ovulation is affected it can be a problem in the fertilization process. For example, females with PCOS (polycystic ovarian syndrome) have problems in the release of mature eggs.
Uterine abnormalities: the female with structural problems of the uterus have trouble conceiving.
Old age: as the woman ages, there are less chances of fertility due to the immature or poor quality egg production.
Low sperm count: less sperm production or abnormal sperms can reduce the chances of fertilization and can lead to infertility.
Abnormal function of sperm: when the movement of sperm is inadequate or the shape of sperm is abnormal, then the sperm cannot fertilize the egg.
In some cases, the cause of infertility cannot be identified despite comprehensive testing. This is referred to as unexplained infertility. 10-20% of infertility cases are unexplained infertility.
The above mentioned conditions are the main reason why couples go for IVF. The couples who have any of the above mentioned conditions are the perfect candidates for IVF.
Preparing for IVF involves several steps, including undergoing medical evaluations, receiving hormonal therapies, and making lifestyle modifications.
Before going for IVF, both partners will undergo medical assessments. These evaluations aim to evaluate overall health and identify any underlying conditions that could affect fertility or the success of IVF. They typically involve:
Physical examination: A thorough examination is conducted to assess general health and identify the issues in both partners.
Medical history: Both partners provide information about their medical backgrounds, including past fertility treatments, surgeries, or known medical conditions.
Fertility tests: Various tests are performed to assess fertility factors like ovarian reserve, sperm quality, and fallopian tube functionality. Blood tests and semen tests are also performed during fertility tests.
The specific hormonal therapies may vary depending on individual requirements and the IVF protocol recommended by the fertility specialist. Common medications used in IVF include:
Birth control pills: Sometimes, birth control pills are prescribed to regulate the menstrual cycle and setting it according to the IVF treatment timeline.
Ovarian stimulation medications: injections are often used to stimulate the ovaries which promotes the production of multiple eggs instead of the typical single egg per cycle. The hormonal therapy used for this purpose are the follicle stimulating hormone or luteinizing hormone.
Hormonal therapy Medications: Gonadotropin-releasing hormone (GnRH) agonists and antagonists, Human chorionic gonadotropin (hCG) and Progesterone supplements may be given for egg retrieval, egg maturation and developmental support.
It is beneficial to make specific lifestyle modifications for the successful IVF.
Healthy eating habits: a balanced diet of fruits, vegetables, whole grains, lean proteins, and healthy fats is recommended. Processed foods, excess sugar, and the excessive consumption of caffeine and alcohol should be avoided.
Regular physical activity: regular exercise is helpful to maintain a healthy weight and improve overall fitness. During IVF, the normal exercise activities are beneficial.
Smoking and alcohol consumption: It is recommended to quit smoking entirely and reduce alcohol intake to improve fertility which also increases the chances of successful IVF.
Effective stress management: the stress-reducing techniques such as mindfulness, yoga, meditation, or counseling is necessary. Properly managing stress is important as it can affect fertility outcomes.
IVF procedure is a complex process which involves various steps. These are:
Suppression of menstrual cycle: The menstrual cycle is suppressed by the use of some specific medications. So that the various eggs can be matured under the effect of medicines and limit the loss of egg in menstruation.
Stimulation of the ovaries: the ovaries are stimulated to produce more mature eggs by the use of some specific medications. This phase is usually of 8-14 days but it can vary according to the condition of each individual’s response to medicines.
Egg retrieval: Once the eggs are mature in ovaries, a minor surgical procedure called egg retrieval is performed. The woman is given a mild sedative or anesthesia to minimize discomfort. The fine needle is inserted through the vagina into the uterus and the egg is extracted. The procedure usually takes about 20-30 minutes.
Sperm collection: the semen from the male partner is collected. The healthy sperms are then separated from the fluid and stored carefully.
Fertilization and embryo development: The retrieved eggs and the stored sperm are combined in a laboratory dish for fertilization. According to the condition and demand, either conventional IVF or intracytoplasmic sperm injection may be used. In conventional IVF, the eggs and sperm are placed together in a culture dish and left to fertilize naturally. In ICSI, a single sperm is directly injected into each mature egg to promote the fertilization.
Embryo transfer: After a few days of development, one or more embryos are selected for transfer into the woman's uterus. A thin catheter is used to transfer the embryos through the vagina into the uterus. This procedure is usually painless.
After the embryo transfer, there is a waiting period of about 10-14 days before a pregnancy test can be done.
The chances of success in in vitro fertilization (IVF) depends on many factors such as the age of woman and the underlying cause of infertility. Mostly in younger women, IVF is more successful. IVF is usually not recommended for women over the age of 42 due to the lower chances of pregnancy. In 2019, the live birth rates for IVF treatments were as follows:
|Age of Women||Percentage|
|Women under 35||32%|
|Women aged 35 to 37||25%|
|Women aged 38 to 39||19%|
|Women aged 40 to 42||11%|
|Women aged 43 to 44||5%|
|Women over 44||4%|
According to a study involving nearly 156,000 women, the initial cycle of in vitro fertilization (IVF) demonstrated a commendable success rate, with an average live-birth rate of 29.5%. The chances of success can further improve with subsequent treatment cycles. In fact, the study reported a cumulative live-birth rate of 65.3% after six rounds of IVF.
The Cost of IVF Treatment in India ranges from approximately 720 USD to 960 USD that also includes the cost of medications. Many couples spend more than 60,000 USD on IVF treatment and procedures due to the failure or previous IVF and the further requirement of multiple cycles of IVF.
Different techniques of IVF treatment cost in India:
|IVF Treatment Cost in India||Min Cost in USD||Max Cost in USD|
|Assisted IVF with Egg Donor:||2200 USD||3000 USD|
|Embryo Donor||400 USD||660 USD|
|Frozen Embryos Transfer||200 USD||360 USD|
|Intracytoplasmic Sperm Injection||2000 USD||2640 USD|
|Other||500 USD||700 USD|
The IVF treatment cost may also vary in different hospitals of different cities in India. This is due to the facilities of hospitals and the availability of the skilled health providers in a single setting. Some of the cost ranges in different cities are described below.
The IVF Treatment Cost in India are as follows:
|City||Min Cost in USD||Max Cost in USD|
|Mumbai||2400 USD||3600 USD|
|Bangalore||1920 USD||2100 USD|
|Chennai||1740 USD||1920 USD|
|Delhi||1080 USD||1500 USD|
|Nagpur||900 USD||1080 USD|
|Hyderabad||840 USD||1080 USD|
The leading IVF center in India, now offers equal opportunities to all infertile foreigners looking for IVF treatments. The center provides a comprehensive range of assisted reproductive technologies, including In-Vitro Fertilization (IVF), Intracytoplasmic Sperm Injection (ICSI), egg freezing, semen cryopreservation, surgical sperm extractions, semen analysis tests, and affordable fertility medications.
India offers various IVF treatments to international couples and also provides a wide range of affordable fertility treatments. The center for IVF in India takes care of the entire IVF process which includes registration, consultations, legal requirements, and the IVF procedure itself. IVF treatments cost in India are significantly more cost-effective as compared to other countries that range from 4000-5500 USD.
Here are some of the risk factors that are associated with in vitro fertilization (IVF):
IVF treatment may stimulate the ovaries excessively that can lead to OHSS. Symptoms can include abdominal discomfort, bloating, nausea, and in severe cases, fluid accumulation in the abdomen and chest.
IVF treatment in India raises the chances of multiple pregnancies. It happens usually when multiple embryos are transferred during IVF to increase the chances of successful IVF. Having multiple pregnancies poses a greater risk of complications such as premature birth of a baby, low birth weight, and developmental challenges for the babies.
In rare cases, the fertilized embryo can implant outside the uterus which is referred to as an ectopic pregnancy. This is a life-threatening condition which requires emergency medical management.
The chances of miscarriage with IVF is similar to that of natural conception. However, the age of mother and the efficacy of the IVF procedure can also affect the chances of a miscarriage.
The process of undergoing IVF treatment can present emotional challenges, including a range of emotions, disappointments, and heightened stress levels. It is crucial to establish a robust support system and have access to counseling or psychological assistance throughout the entire process to navigate these emotional and psychological impacts effectively.
There is a slight increase in the risk of having birth defects among babies that are born through IVF technique. But the overall risk of these birth defects is relatively low.
Surrogacy and in vitro fertilization (IVF) are both methods which are used in assisted reproductive technology (ART) to help individuals or couples in achieving pregnancy. They both are completely different processes with unique characteristics.
Surrogacy involves a woman, known as the surrogate, carrying a pregnancy on behalf of another person or couple, referred to as the intended parents. While IVF is a fertility treatment that involves combining eggs and sperm outside the body in a laboratory setting.
The process of in vitro fertilization (IVF) can be emotionally and psychologically challenging for individuals and couples undergoing the treatment. Here are some of the emotional and psychological aspects that are associated with IVF:
Hope and Anticipation: IVF represents a significant step towards pregnancy for those facing infertility that can lead to a mix of emotions like excitement and anxiety.
Stress and Anxiety: The IVF process can be stressful due to factors such as physical demands, financial implications, and chances of failure of IVF. Frequent medical appointments, hormone injections, and the wait for test results can increase the anxiety level.
Emotional Roller Coaster: IVF involves multiple stages, each with its own emotional impact. Optimism and disappointment can alternate throughout the process that depends on the outcomes achieved.
Emotional Investment: IVF requires a significant emotional investment as individuals and couples invest their hopes, dreams, and resources into the treatment. This attachment can intensify stress, sadness, and frustration if the desired outcome is not achieved.
Strained Relationships: The demands of IVF can strain relationships as couples navigate the emotional and physical aspects of the treatment. Pressure to conceive and repeated disappointments can lead to tension, conflicts, and decreased intimacy.
Social and Cultural Factors: IVF may involve managing societal and cultural expectations surrounding fertility and family-building. Individuals and couples may face judgment, stigma, or intrusive questions, which can contribute to emotional distress.
Concerns and misconceptions about IVF:
High cost: IVF can be expensive, creating a barrier for many individuals or couples seeking fertility treatments. Insurance coverage for IVF is becoming more common in some countries, and there are various financial assistance programs available.
Low success rates: IVF success rates vary based on factors like age, cause of infertility, and embryo quality. While success rates have improved, it is not a guaranteed solution for everyone. Realistic expectations and consultations with fertility specialists are important.
Ethical and religious concerns: IVF raises ethical and religious concerns regarding embryo creation and disposition and use of sperms other than the partner. Individuals should consult religious or spiritual advisors to address these concerns based on their beliefs.
Long-term health effects: it is said that IVF babies suffer from long term health effects but there is limited evidence to this.
Multiple pregnancies: IVF increases the chances of multiple pregnancies, such as twin babies or triplets.
Health risk for mother and child: IVF can be the reason for health risks for both mother and child but there is limited studies that support the idea of health risk for IVF babies.
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